(4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

Base Information

Chemical Name:(4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol
CAS No.:1356465-57-0
Molecular Formula:C₂₁H₂₁ClN₂O₃
Molecular Weight:384.862
Hs Code.:

Synonyms:(4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

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Chemical Property of (4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

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Technology Process of (4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

There total 3 articles about (4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: N'-hydroxy-4-(hydroxymethyl)benzimidamide

: 1356465-54-7
2-((1-(4-chlorophenyl)cyclobutyl)methoxy)acetic acid

: 1356465-57-0
(4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

Guidance literature:: N'-hydroxy-4-(hydroxymethyl)benzimidamide; 2-((1-(4-chlorophenyl)cyclobutyl)methoxy)acetic acid; With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 2.25h;

With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 1.83333h;

Reference yield:

: 50921-41-0
1-(4-chlorophenyl)cyclobutylmethanol

: 1356465-57-0
(4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene / 0.5 h / 0 °C / Cooling with ice

1.2: 16.83 h / 20 °C

2.1: trifluoroacetic acid / 0.62 h / 20 °C

3.1: diisopropyl-carbodiimide / dichloromethane / 2.25 h / 20 °C

3.2: 1.83 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; trifluoroacetic acid; sodium hydroxide; diisopropyl-carbodiimide; In dichloromethane; toluene;

Reference yield:

: 1356465-56-9
tert-butyl 2-((1-(4-chlorophenyl)cyclobutyl) methoxy)acetate

: 1356465-57-0
(4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 0.62 h / 20 °C

2.1: diisopropyl-carbodiimide / dichloromethane / 2.25 h / 20 °C

2.2: 1.83 h / 20 °C

With trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;