3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole
CAS No.:1356465-58-1
Molecular Formula:C₂₁H₂₀BrClN₂O₂
Molecular Weight:447.759
Hs Code.:

Synonyms:3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole

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Chemical Property of 3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole

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Technology Process of 3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole

There total 4 articles about 3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1356465-57-0
(4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

: 1356465-58-1
3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole

Guidance literature:: (4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol; With phosphorus tribromide; In dichloromethane; for 16h; Cooling with ice;

With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 1.83333h;

Reference yield:

: 50921-41-0
1-(4-chlorophenyl)cyclobutylmethanol

: 1356465-58-1
3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene / 0.5 h / 0 °C / Cooling with ice

1.2: 16.83 h / 20 °C

2.1: trifluoroacetic acid / 0.62 h / 20 °C

3.1: diisopropyl-carbodiimide / dichloromethane / 2.25 h / 20 °C

3.2: 1.83 h / 20 °C

4.1: phosphorus tribromide / dichloromethane / 16 h / Cooling with ice

4.2: 1.83 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; phosphorus tribromide; trifluoroacetic acid; sodium hydroxide; diisopropyl-carbodiimide; In dichloromethane; toluene;

Reference yield:

: 1356465-56-9
tert-butyl 2-((1-(4-chlorophenyl)cyclobutyl) methoxy)acetate

: 1356465-58-1
3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl) methoxy)methyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 0.62 h / 20 °C

2.1: diisopropyl-carbodiimide / dichloromethane / 2.25 h / 20 °C

2.2: 1.83 h / 20 °C

3.1: phosphorus tribromide / dichloromethane / 16 h / Cooling with ice

3.2: 1.83 h / 20 °C

With phosphorus tribromide; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;