benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate

Base Information

Chemical Name:benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate
CAS No.:121142-33-4
Molecular Formula:C₃₅H₄₈N₂O₉
Molecular Weight:640.774
Hs Code.:

Synonyms:benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate

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Chemical Property of benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate

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Technology Process of benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate

There total 4 articles about benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2483-46-7
Boc-Lys(Boc)-OH

: 121142-33-4
benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) isobutyl chloroformate, TEA / 1) Et₂O, -15 deg C, 15 min, 2) Et₂O, -15 deg C, 2 h

2: 88 percent / HBr / diethyl ether; dioxane / 5 °C

3: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; TEA; hydrogen bromide; sodium hydride; isobutyl chloroformate; In 1,4-dioxane; diethyl ether;
DOI:10.1021/jm00126a039

Reference yield:

: 121142-28-7
(3S)-3,7-bis<(tert-butyloxycarbonyl)amino>-1-diazo-2-oxoheptane

: 121142-33-4
benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / HBr / diethyl ether; dioxane / 5 °C

2: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen bromide; sodium hydride; In 1,4-dioxane; diethyl ether;
DOI:10.1021/jm00126a039

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 121142-33-4
benzyl (5S)-2-(benzyloxycarbonyl)-5,9-bis<(tert-butyloxycarbonyl)amino>-2-methyl-4-oxononanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH, HMPA / 1) DMF, 25 deg C, 30 min, 2) 25 deg C, 3 h

2: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride;
DOI:10.1021/jm00126a039