(3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester
CAS No.:905991-67-5
Molecular Formula:C₂₀H₂₈ClNO₄S₂
Molecular Weight:446.032
Hs Code.:

Synonyms:(3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester

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Chemical Property of (3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester

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Technology Process of (3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester

There total 4 articles about (3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2-[2-chloro-4-(2-methoxy-2-oxoethyl)phenoxy]-N-methylethanamine hydrochloride

: 1077-28-7,62-46-4
Thioctic acid

: 905991-67-5
(3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: Thioctic acid; With isopropyl chloroformate; triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

2-[2-chloro-4-(2-methoxy-2-oxoethyl)phenoxy]-N-methylethanamine hydrochloride; With triethylamine; In dichloromethane; toluene; at 0 ℃; for 1h;
DOI:10.1021/jm0510880

Reference yield:

: 905991-54-0
methyl (4-{2-[(tert-butoxycarbonyl)(methyl)amino]ethoxy}-3-chlorophenyl)acetate

: 905991-67-5
(3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / HCl / dioxane; diethyl ether / 0.5 h / 0 °C

2.1: Et₃N; isopropyl chloroformate / CH₂Cl₂ / 0.17 h / 0 °C

2.2: 79 percent / Et₃N / CH₂Cl₂; toluene / 1 h / 0 °C

With hydrogenchloride; isopropyl chloroformate; triethylamine; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/jm0510880

Reference yield:

: 33697-81-3
(3-chloro-4-hydroxy-phenyl)-acetic acid

: 905991-67-5
(3-chloro-4-{2-[(5-[1,2]dithiolan-3-yl-pentanoyl)-methyl-amino]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / H₂SO₄ / 6 h / Heating

2.1: 69 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C

3.1: 93 percent / HCl / dioxane; diethyl ether / 0.5 h / 0 °C

4.1: Et₃N; isopropyl chloroformate / CH₂Cl₂ / 0.17 h / 0 °C

4.2: 79 percent / Et₃N / CH₂Cl₂; toluene / 1 h / 0 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sulfuric acid; isopropyl chloroformate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; 2.1: Mitsunobu reaction;
DOI:10.1021/jm0510880