3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide

Base Information

Chemical Name:3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide
CAS No.:1095003-78-3
Molecular Formula:C₂₃H₂₆N₄O₄
Molecular Weight:422.484
Hs Code.:

Synonyms:3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide

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Chemical Property of 3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide

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Technology Process of 3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide

There total 7 articles about 3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095005-68-7
methyl 3-(3-((1R,2R)-3-hydroxy-2-methyl-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 593-56-6
N-methoxylamine hydrochloride

: 1095003-78-3
3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide

Guidance literature:: methyl 3-(3-((1R,2R)-3-hydroxy-2-methyl-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate; N-methoxylamine hydrochloride; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.25h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095003-78-3
3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,2-dichloro-benzene / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 50 °C

3: ammonium formate; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 2 h / 70 °C

4: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

With isopropylmagnesium chloride; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; 1,2-dichloro-benzene;

Reference yield:

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095003-78-3
3-[3-[[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-methoxy-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 50 °C

2: ammonium formate; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 2 h / 70 °C

3: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

With isopropylmagnesium chloride; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;