S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate

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Chemical Name:S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate
CAS No.:1609547-87-6
Molecular Formula:C₃₁H₃₃Cl₂N₅O₅S₃
Molecular Weight:722.738
Hs Code.:

Synonyms:S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate

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Chemical Property of S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate

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Technology Process of S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate

There total 3 articles about S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 19194-55-9
O-ethyl S-phthalimidomethyl dithiocarbonate

: 1609547-75-2
N-(4-allyl-1-tosylpiperidin-4-yl)-4,6-dichloropyrimidin-2-amine

: 1609547-87-6
S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate

Guidance literature:: With dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;
DOI:10.1021/ol501104h

Reference yield:

: 33439-27-9
N-tosyl-4-piperidone

: 1609547-87-6
S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol / 0.25 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 72 h / 90 °C / Inert atmosphere; Sealed tube

3.1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

With dilauryl peroxide; ammonia; triethylamine; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/ol501104h

Reference yield:

: 1414889-98-7
4-allyl-1-tosylpiperidin-4-amine

: 1609547-87-6
S-(1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)-4-(1,3-dioxoisoindolin-2-yl)butan-2-yl)-O-ethyl carbonodithioate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 72 h / 90 °C / Inert atmosphere; Sealed tube

2: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

With dilauryl peroxide; triethylamine; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ol501104h