33439-27-9

Basic information

• Product Name: 1-Tosylpiperidin-4-one
• Synonyms: 1-Tosylpiperidin-4-one;1-Tosyl-4-piperidone
• CAS NO: 33439-27-9
• Molecular Formula: C₁₂H₁₅NO₃S
• Molecular Weight: 253.3174
• Mol File: 33439-27-9.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-Tosylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Tosylpiperidin-4-one(33439-27-9)
• EPA Substance Registry System: 1-Tosylpiperidin-4-one(33439-27-9)

Safety Data

• Hazardous Substances Data: 33439-27-9(Hazardous Substances Data)

Usage

General Description

1-Tosylpiperidin-4-one, also known as 1-(4-methylphenyl)sulfonylpiperidin-4-one, is a chemical compound with the molecular formula C13H17NO2S. It is a white to off-white crystalline powder and is commonly used as an intermediate in the synthesis of pharmaceutical compounds and organic chemicals. 1-Tosylpiperidin-4-one is a derivative of piperidin-4-one, and its tosyl group makes it an important building block in organic synthesis. It is used in the production of various pharmaceuticals, including antipsychotic and anti-inflammatory drugs, as well as in the preparation of other chemicals such as agrochemicals and dyes. Due to its versatile nature and importance in organic synthesis, 1-Tosylpiperidin-4-one is widely utilized in the pharmaceutical and chemical industries.

Upstream product

• 80213-12-3 1-[(4-methylbenzene)-sulfonyl]-4-piperidinol 
• 41979-39-9 4-piperidone hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 553666-09-4 1-[(4-methylphenyl)sulfonyl]piperidine-4-carbaldehyde 
• 50675-20-2 piperidine-4-carbaldehyde 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 40064-34-4 piperidine-4,4-diol hydrochloride 
• 1217800-93-5 C₁₃H₁₇NO₃S 
• 41661-47-6 piperidin-4-one 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 5382-16-1 4-HYDROXYPIPERIDINE 

Downstream Products

• 82420-15-3 1-Tosyl-4-(3-indolyl)-1,2,5,6-tetrahydropyridine 
• 87943-01-9 4-(phenylethynyl)-1-tosylpiperidin-4-ol 
• 171009-41-9 O-ethyl-S-(4-oxo-1-tosylpiperidin-3-yl)carbonodithioate 
• 606926-42-5 N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine 
• 852051-00-4 1-(toluene-4-sulfonyl)-2,3-dehydro-4-piperidone 
• 83863-40-5 4-phenyl-1-(p-tolylsulfonyl)piperidin-4-ol 
• 158584-98-6 4-hydroxy-3-[4-(phenylmethoxy)benzoylamino]-1-(phenylmethoxycarbonyl)-hexahydroazepine 
• 171009-43-1 3-bromo-1-(4'-methylphenylsulfonyl)azepan-4-one 
• 171009-44-2 3-azido-1-(4'-methylphenylsulfonyl)azepan-4-one 
• 171009-42-0 3-bromo-5-ethoxycarbonyl-1-(4'-methylphenylsulfonyl)azepan-4-one 

Relevant articles and documents

Synthesis of novel 1,3-thiazin-4-ones by acetylene diester cyclization and their anticancer activities

A novel series of 1,3-thiazin-4-one derivatives containing a piperidyl ring (7–16) were designed and synthesized efficiently by thioamide and acetylene diester cyclization reaction via aminolysis of the ester group and the elimination of an alcohol molecu

Metal-free Photochemical Atom Transfer Radical Addition (ATRA) of BrCCl3 to Alkenes

A simple, photochemical, and metal-free protocol for the atom transfer radical addition (ATRA) of bromotrichloromethane onto various alkenes is described. Among a range of organic molecules, phenylglyoxylic acid proved to be the most suitable photoinitiator to promote a sustainable process for the addition of bromotrichloromethane to olefins. This photochemical atom transfer radical protocol can be expanded into a wide substrate scope of aliphatic olefins bearing various functional groups, leading to the corresponding products in good to excellent yields.

Synthesis of α-Quaternary Bicyclo[1.1.1]pentanes through Synergistic Organophotoredox and Hydrogen Atom Transfer Catalysis

Bicyclo[1.1.1]pentanes (BCPs) are important in drug design as sp3-rich bioisosteres of arenes and tert-butyl groups; however, the preparation of BCPs with adjacent quaternary carbons is barely known. We report a facile synthesis of α-quaternary BCPs using organophotoredox and hydrogen atom transfer catalysis in which α-keto radicals, generated through oxidation of β-ketocarbonyls, undergo efficient addition to [1.1.1]propellane. The BCP products can be transformed into a variety of useful derivatives, including enantioenriched BCPs featuring α-quaternary stereocenters.