(E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester

Base Information

• Chemical Name: (E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester
• CAS No.: 172536-39-9
• Molecular Formula: C₁₆H₁₈N₂O₄
• Molecular Weight: 302.33

Synonyms:(E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester

Chemical Property of (E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester

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Technology Process of (E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester

There total 2 articles about (E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-phenyl-3-acetyl-4-formyl-4-methyl-1,3-diazetidin-2-one (86625-62-9) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → (E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester (172536-39-9)

Guidance literature:

In benzene; for 1h; Ambient temperature;

DOI:10.1039/a802438c

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 1-phenyl-3-acetyl-4-formyl-4-methyl-1,3-diazetidin-2-one (86625-62-9) → (E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester (172536-39-9)

Guidance literature:

With sodium hydride;

DOI:10.1016/0040-4039(95)01473-U

Reference yield: 99.0%

(E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester (172536-39-9) → 3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester (172536-40-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; Ambient temperature;

DOI:10.1039/a802438c

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

1-phenyl-3-acetyl-4-formyl-4-methyl-1,3-diazetidin-2-one

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester

4-(3-Hydroxy-propyl)-4-methyl-1-phenyl-[1,3]diazetidin-2-one

[2-Methyl-4-oxo-2-(3-oxo-propyl)-3-phenyl-[1,3]diazetidin-1-yl]-acetic acid ethyl ester

6-Methyl-8-oxo-7-phenyl-1,7-diaza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid ethyl ester

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