3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester
• CAS No.: 172536-40-2
• Molecular Formula: C₁₆H₂₀N₂O₄
• Molecular Weight: 304.346

Synonyms:3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester

Chemical Property of 3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester

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Technology Process of 3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester

There total 2 articles about 3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester (172536-39-9) → 3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester (172536-40-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; Ambient temperature;

DOI:10.1039/a802438c

Reference yield:

1-phenyl-3-acetyl-4-formyl-4-methyl-1,3-diazetidin-2-one (86625-62-9) → 3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester (172536-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / benzene / 1 h / Ambient temperature

2: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethyl acetate; benzene;

DOI:10.1039/a802438c

Reference yield: 68.0%

3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-propionic acid ethyl ester (172536-40-2) → 4-(3-Hydroxy-propyl)-4-methyl-1-phenyl-[1,3]diazetidin-2-one (172536-41-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1039/a802438c

upstream raw materials:

(E)-3-(1-Acetyl-2-methyl-4-oxo-3-phenyl-[1,3]diazetidin-2-yl)-acrylic acid ethyl ester

1-phenyl-3-acetyl-4-formyl-4-methyl-1,3-diazetidin-2-one

Downstream raw materials:

4-(3-Hydroxy-propyl)-4-methyl-1-phenyl-[1,3]diazetidin-2-one

[2-Methyl-4-oxo-2-(3-oxo-propyl)-3-phenyl-[1,3]diazetidin-1-yl]-acetic acid ethyl ester

6-Methyl-8-oxo-7-phenyl-1,7-diaza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid ethyl ester

4-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-methyl-1-phenyl-[1,3]diazetidin-2-one

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