4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine

Base Information

• Chemical Name: 4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine
• CAS No.: 1388893-90-0
• Molecular Formula: C₂₀H₂₉N₃O₂S
• Molecular Weight: 375.535

Synonyms:4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine

Chemical Property of 4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine

Chemical Property:

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Technology Process of 4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine

There total 9 articles about 4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C24H35N3O4S → 4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1(8),2(6),9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine (1388893-90-0)

Guidance literature:

With formic acid; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate (1029689-54-0) → 4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1(8),2(6),9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine (1388893-90-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 20 - 180 °C / Inert atmosphere

1.2: Cooling with ice

2.1: trichlorophosphate / 20 - 110 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

5.2: Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

6.2: 20 °C

7.1: formic acid / 12 h / 100 °C / Inert atmosphere

With lithium aluminium tetrahydride; formic acid; sodium hydride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

ethyl (2-oxocyclopentyl)acetate (20826-94-2) → 4-[[3-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1(8),2(6),9,11-tetraen-12-yl]oxy]-N,N-dimethylcyclohexan-1-amine (1388893-90-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: diethylamine; sulfur / ethanol / 20 °C

2.1: 20 - 180 °C / Inert atmosphere

2.2: Cooling with ice

3.1: trichlorophosphate / 20 - 110 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

6.2: Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

7.2: 20 °C

8.1: formic acid / 12 h / 100 °C / Inert atmosphere

With lithium aluminium tetrahydride; formic acid; sodium hydride; sulfur; diethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

formaldehyd

ethyl (2-oxocyclopentyl)acetate

ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

ethyl 2-[12-hydroxy-7-thia-9,11-diazatricyclo[6.4.0.0[2.6]]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-3-yl]acetate

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