2-[4-(4-Chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide

Base Information

Chemical Name:2-[4-(4-Chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide
CAS No.:361436-79-5
Molecular Formula:C₁₇H₁₁ClFN₃O₂
Molecular Weight:343.745
Hs Code.:
DSSTox Substance ID:DTXSID20432389
Wikidata:Q82246455

Synonyms:2-(4-(4-chloro-2-fluorophenoxy)phenyl)pyrimidine-4-carboxamide;PPPA cpd

Suppliers and Price of 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:343.0523825
Heavy Atom Count:24
Complexity:434

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC=CC(=N2)C(=O)N)OC3=C(C=C(C=C3)Cl)F

Technology Process of 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide

There total 5 articles about 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2-[4-(4-chloro-2-fluorophenoxy)-phenyl]-pyrimidine-4-carboxylic acid methyl ester

: 7664-41-7
ammonia

: 361436-79-5
2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide

Guidance literature:: In proof alcohol; at 20 - 55 ℃; for 94h;

Reference yield: 65.0%

: 2-[4-(4-chloro-2-fluorophenoxy)-phenyl]-pyrimidine-4-carboxylic acid ethyl ester

: 7664-41-7
ammonia

: 361436-79-5
2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide

Guidance literature:: 2-[4-(4-chloro-2-fluorophenoxy)-phenyl]-pyrimidine-4-carboxylic acid ethyl ester; With 1-methyl-pyrrolidin-2-one; at 80 - 100 ℃; for 1h; activated powdered carbon

ammonia; at 0 - 20 ℃; for 2h;