ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Base Information

• Chemical Name: ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
• CAS No.: 688313-59-9
• Molecular Formula: C₁₇H₁₃ClF₂N₂O₂
• Molecular Weight: 350.752
• Mol file: 688313-59-9.mol

Synonyms:ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Chemical Property of ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

There total 2 articles about ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

3-chloro-2,6-difluorobenzyl bromide (261762-47-4) + ethyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate (147503-82-0) → ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (688313-59-9)

Guidance literature:

ethyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 10 ℃; for 2.25h; Inert atmosphere;

3-chloro-2,6-difluorobenzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 10 - 20 ℃;

DOI:10.1021/jm900862n

Reference yield:

→ ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (688313-59-9)

Guidance literature:

Reference yield: 72.0%

ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (688313-59-9) → 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid (688313-60-2)

Guidance literature:

ethyl 1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With water; sodium hydroxide; In methanol; at 100 ℃; for 0.0833333h; Microwave irradiation;

With citric acid; In methanol; water; pH=2 - 3;

DOI:10.1021/jm900862n

upstream raw materials:

3-chloro-2,6-difluorobenzyl bromide

ethyl 1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Downstream raw materials:

1-(3-chloro-2,6-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid