N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

Base Information

Chemical Name:N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide
CAS No.:1227845-76-2
Molecular Formula:C₁₉H₂₀F₂N₂O₃
Molecular Weight:362.376
Hs Code.:

Synonyms:N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

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Chemical Property of N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

Chemical Property:

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Technology Process of N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

There total 4 articles about N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1181770-76-2
2-ethyl-4-methoxy-3-methylbenzoic acid

: 797784-35-1
2-(3,4-difluorophenyl)-acetic hydrazide

: 1227845-76-2
N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 5628-61-5
4-methoxy-2,3-dimethyl-benzoic acid

: 1227845-76-2
N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -78 - -65 °C / Inert atmosphere

1.2: -78 °C

1.3: 0.5 h / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With sec.-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 210530-71-5
(3,4-difluoro-phenyl)-acetic acid methyl ester

: 1227845-76-2
N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / isopropyl alcohol / 18 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; isopropyl alcohol;