N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Base Information

Chemical Name:N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide
CAS No.:1227845-44-4
Molecular Formula:C₁₈H₁₈F₂N₂O₃
Molecular Weight:348.349
Hs Code.:

Synonyms:N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

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Chemical Property of N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Chemical Property:

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Technology Process of N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

There total 5 articles about N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1227845-76-2
N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide

: 1227845-44-4
N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Guidance literature:: N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide; With boron tribromide; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

With water; In dichloromethane; Cooling with ice;

Reference yield:

: 5628-61-5
4-methoxy-2,3-dimethyl-benzoic acid

: 1227845-44-4
N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -78 - -65 °C / Inert atmosphere

1.2: -78 °C

1.3: 0.5 h / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere

3.2: Cooling with ice

With sec.-butyllithium; boron tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 210530-71-5
(3,4-difluoro-phenyl)-acetic acid methyl ester

: 1227845-44-4
N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / isopropyl alcohol / 18 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere

3.2: Cooling with ice

With boron tribromide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;