N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide

Base Information

• Chemical Name: N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide
• CAS No.: 1258239-63-2
• Molecular Formula: C₁₄H₁₈N₂O₂
• Molecular Weight: 246.309
• Mol file: 1258239-63-2.mol

Synonyms:N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide

Chemical Property of N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide

There total 4 articles about N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + p-aminoethylbenzoate (94-09-7) → N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide (1258239-63-2)

Guidance literature:

With Cumene hydroperoxide; iodine; In tert-butyl methyl ether; at 55 ℃; for 24h;

DOI:10.1021/acs.orglett.5b00722

Reference yield: 49.0%

TiCl2(N-tert-butylimido)bischlorobis(pyridine)titanium(IV) (190712-80-2) + p-ethoxycarbonylphenyl isocyanate (30806-83-8) → N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide (1258239-63-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2010.09.073

Reference yield:

tert-butylisonitrile (119072-55-8,7188-38-7) + 4-azido-benzoic acid ethyl ester (38556-93-3) → N'-tert-butyl-N-4-(ethoxycarbonyl)phenyl carbodiimide (1258239-63-2)

Guidance literature:

4-azido-benzoic acid ethyl ester; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 0.0833333h; Sealed tube; Inert atmosphere; Green chemistry;

tert-butylisonitrile; In tetrahydrofuran; at 20 ℃; for 5h; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.1039/c5cc05981j

upstream raw materials:

TiCl₂(N-tert-butylimido)bischlorobis(pyridine)titanium(IV)

p-ethoxycarbonylphenyl isocyanate

tert-butylisonitrile

p-aminoethylbenzoate

Downstream raw materials:

N'-tert-butyl-N-4-ethoxycarbonylphenyl urea

Refernces

• 1、 Zhang, Zhen,Li, Zongyang,Fu, Bin,Zhang, Zhenhua. "Palladium-catalyzed cross-coupling reaction of azides with isocyanides". . p. 16312 - 16315. Retrieved 2015/11/16.