(2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester

Base Information

• Chemical Name: (2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester
• CAS No.: 577974-10-8
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.373
• Mol file: 577974-10-8.mol

Synonyms:(2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester

Chemical Property of (2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester

There total 7 articles about (2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(E)-tert-Butoxycarbonylimino]-acetic acid ethyl ester (81357-11-1) + (1-phenylvinyl)carbamic acid benzyl ester (697301-71-6) → (2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester (577974-10-8) + (2S)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester

Guidance literature:

[(E)-tert-Butoxycarbonylimino]-acetic acid ethyl ester; (1-phenylvinyl)carbamic acid benzyl ester; With (1R,2R)-N,N’-bis(2-methoxybenzyl)-1,2-diphenylethane-1,2-diamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 0 ℃;

With hydrogen bromide; In methanol; water; Title compound not separated from byproducts;

DOI:10.1002/anie.200353237

Reference yield:

1-styrenyloxytrimethylsilane (13735-81-4) + [(E)-tert-Butoxycarbonylimino]-acetic acid ethyl ester (81357-11-1) → (2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester (577974-10-8) + (2S)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester

Guidance literature:

1-styrenyloxytrimethylsilane; [(E)-tert-Butoxycarbonylimino]-acetic acid ethyl ester; With (1R,2R)-N,N’-bis(2-methylbenzyl)-1,2-diphenylethane-1,2-diamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1021/ol034717d

Reference yield:

α-methoxystyrene (4747-13-1) + [(E)-tert-Butoxycarbonylimino]-acetic acid ethyl ester (81357-11-1) → (2R)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester (577974-10-8) + (2S)-2-tert-butoxycarbonylamino-4-oxo-4-phenylbutyric acid ethyl ester

Guidance literature:

α-methoxystyrene; [(E)-tert-Butoxycarbonylimino]-acetic acid ethyl ester; With (1R,2R)-N,N’-bis(2-methylbenzyl)-1,2-diphenylethane-1,2-diamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -78 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/ol034717d

upstream raw materials:

1-styrenyloxytrimethylsilane

[(E)-tert-Butoxycarbonylimino]-acetic acid ethyl ester

α-methoxystyrene

(1-ethoxyvinyl)benzene

Downstream raw materials:

(2R)-2-dodecanoylamino-4-oxo-4-phenylbutyric acid ethyl ester hydrochloride