Technology Process of 3-(2-((tert-butyldiphenylsilyloxy)methyl)phenyl)but-3-ene-1-thiol
There total 12 articles about 3-(2-((tert-butyldiphenylsilyloxy)methyl)phenyl)but-3-ene-1-thiol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -10 ℃;
DOI:10.1002/ejoc.201402157
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -78 - 20 °C
2.2: 2 h / 25 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C
3.2: 23 °C
4.1: camphor-10-sulfonic acid / methanol / 0 °C
5.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C
6.1: N,N-dimethyl-formamide / 12 h / 0 - 20 °C
7.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 °C
With
1H-imidazole; dmap; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1002/ejoc.201402157
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C
1.2: 23 °C
2.1: camphor-10-sulfonic acid / methanol / 0 °C
3.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C
4.1: N,N-dimethyl-formamide / 12 h / 0 - 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 °C
With
dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201402157
