1628058-69-4Relevant academic research and scientific papers
Prins spirocyclization for the synthesis of spiro[isobenzofuran-pyran] derivatives
Reddy, B. V. Subba,Kumar, Harish,Reddy, P. Sivaramakrishna,Singarapu, Kiran Kumar
, p. 4234 - 4238 (2014/07/21)
A Prins cascade process was developed for the synthesis of tetrahydro-3H-spiro[isobenzofuran-pyran] derivatives in good yields and selectivity by the condensation of 3-[2-(hydroxymethyl)phenyl]but-3-en-1-ols with aldehydes or ketones. The reaction proceeds smoothly in the presence of indium(III) trifluoromethanesulfonate (30 mol-%) in dichloroethane at 80 C. This is the first report on the synthesis of tetrahydro-3H-spiro[isobenzofuran- pyran] scaffolds through a Prins cascade reaction. Copyright
