Technology Process of 22-<oxy>docosan-1-ol
There total 4 articles about 22-<oxy>docosan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride; acetic acid;
In
tetrahydrofuran;
for 16h;
DOI:10.1021/jo00126a066
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 46.7 percent / imidazole / dimethylformamide / 24 h / 60 - 65 °C
2: 1.) Et3N / 1.) ether, room temperature, 16 h, 2.) 24 h
3: 62 percent / TBAF, glacial acetic acid / tetrahydrofuran / 16 h
With
1H-imidazole; tetrabutyl ammonium fluoride; acetic acid; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00126a066
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) BH3*THF, 2.) 2 M NaOH, 30percent aq. H2O2 / 1.) THF, 2 deg C, 0.5 h; 2 to 45 deg C, 3 h, 2.) 0.5 h
2: 46.7 percent / imidazole / dimethylformamide / 24 h / 60 - 65 °C
3: 1.) Et3N / 1.) ether, room temperature, 16 h, 2.) 24 h
4: 62 percent / TBAF, glacial acetic acid / tetrahydrofuran / 16 h
With
1H-imidazole; sodium hydroxide; borane-THF; tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00126a066
