1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

Base Information

Chemical Name:1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
CAS No.:895524-46-6
Molecular Formula:C₂₀H₂₃F₃N₄O₅
Molecular Weight:456.422
Hs Code.:

Synonyms:1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

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Chemical Property of 1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

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Technology Process of 1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

There total 1 articles about 1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 640287-98-5
1-(3-(aminomethyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 73488-76-3
N-t-butyloxycarbonyl-alanine-N'-hydroxysuccinimide ester

: 895524-46-6
1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: 1-(3-(aminomethyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid; N-t-butyloxycarbonyl-alanine-N'-hydroxysuccinimide ester; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; water; pH=~ 2;

Reference yield:

: 895524-46-6
1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 613-94-5
benzoic acid hydrazide

: 1-(3-((2-(tert-butoxycarbonyl)aminopropanamido)methyl)phenyl)-N'-benzoyl-3-(trifluoromethyl)-1H-pyrazole-5-carbohydrazide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 895524-46-6
1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 100-46-9
benzylamine

: C₂₇H₃₀F₃N₅O₄

Guidance literature:: 1-(3-((2-(tert-butoxycarbonyl)propanamido)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

benzylamine; In 1,2-dichloro-ethane; at 20 - 65 ℃; for 25h;