(S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

Base Information

Chemical Name:(S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride
CAS No.:1400705-97-6
Molecular Formula:C₂₀H₂₇N₅O₄*ClH
Molecular Weight:437.926
Hs Code.:

Synonyms:(S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

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Chemical Property of (S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

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Technology Process of (S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

There total 10 articles about (S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1400705-96-5
(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester

: 1400705-97-6
(S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; for 1h;

Reference yield:

: 1416162-91-8
2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

: 1400705-97-6
(S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C

2: hydrogenchloride / methanol; 1,4-dioxane / 1 h

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 18655-52-2
3-(3-methoxyphenyl)propan-1-amine

: 1400705-97-6
(S)-3-amino-2-({2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carbonyl}amino)propionic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 1.5 h / 160 °C / Microwave irradiation

2: boron tribromide / dichloromethane / 2 h / 20 °C

3: lithium hydroxide; water / 1,4-dioxane / 12 h / 90 °C

4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 1 h

With hydrogenchloride; water; boron tribromide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;