2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

Base Information

Chemical Name:2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid
CAS No.:1416162-91-8
Molecular Formula:C₁₆H₁₉N₃O₃
Molecular Weight:301.345
Hs Code.:

Synonyms:2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

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Chemical Property of 2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

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Technology Process of 2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

There total 8 articles about 2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400705-44-3
2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester

: 1416162-91-8
2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; at 90 ℃; for 12h;

Reference yield:

: 10516-71-9
3-(3-Methoxy-phenyl)-propionic acid

: 1416162-91-8
2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; isopropyl chloroformate / tetrahydrofuran; toluene / 0.83 h / 0 °C

1.2: 2 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 4 h / Reflux

3.1: ethanol / 1.5 h / 160 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 2 h / 20 °C

5.1: lithium hydroxide; water / 1,4-dioxane / 12 h / 90 °C

With 4-methyl-morpholine; borane-THF; water; boron tribromide; isopropyl chloroformate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 17994-56-8,64612-96-0,123410-61-7
ethyl 4,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1416162-91-8
2-[3-(3-hydroxyphenyl)propylamino]-4,6-dimethylpyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid / 0.25 h / 0 °C

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 2 h / 110 °C

3: ethanol / 1.5 h / 160 °C / Microwave irradiation

4: boron tribromide / dichloromethane / 2 h / 20 °C

5: lithium hydroxide; water / 1,4-dioxane / 12 h / 90 °C

With water; nitric acid; boron tribromide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane;