N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide
CAS No.:1269652-73-4
Molecular Formula:C₁₉H₁₈F₃N₇O₃S
Molecular Weight:481.458
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide

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Chemical Property of N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide

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Technology Process of N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide

There total 6 articles about N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1549-50-4
N-(4-fluoro-phenyl)-[1,3,5]triazine-2,4-diamine

: 1268830-96-1
phenyl 2,6-difluoro-3-(propylsulfonamido)phenylcarbamate

: 1269652-73-4
N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide

Guidance literature:: In dimethyl sulfoxide; at 80 - 130 ℃; for 2h;

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1269652-73-4
N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 2 h / Cold water bath

2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cool water bath

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

5.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 3 h / 20 °C

5.2: 3 h / 100 °C

6.1: dimethyl sulfoxide / 2 h / 80 - 130 °C

With diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 84832-01-9
methyl 2,6-difluoro-3-nitrobenzoate

: 1269652-73-4
N-(2,4-difluoro-3-(3-(4-(4-fluorophenylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cool water bath

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 3 h / 20 °C

4.2: 3 h / 100 °C

5.1: dimethyl sulfoxide / 2 h / 80 - 130 °C

With diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide;