2,6-Difluoro-3-(propylsulfonaMido)benzoic acid

Base Information

• Chemical Name: 2,6-Difluoro-3-(propylsulfonaMido)benzoic acid
• CAS No.: 1103234-56-5
• Molecular Formula: C10H11F2NO4S
• Molecular Weight: 279.264
• Hs Code.: 2935009090
• Mol file: 1103234-56-5.mol

Synonyms:2,6-Difluoro-3-[[(propan-1-yl)sulfonyl]amino]benzoic acid;

Chemical Property of 2,6-Difluoro-3-(propylsulfonaMido)benzoic acid

Chemical Property:

• Melting Point: 205～208℃
• Boiling Point: 394.521 °C at 760 mmHg
• PKA: 2.11±0.10(Predicted)
• Flash Point: 192.4 °C
• PSA: 91.85000
• Density: 1.519 g/cm³
• LogP: 2.96850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,6-Difluoro-3-(propylsulfonamido)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Difluoro-3-(propylsulfonaMido)benzoic acid

There total 13 articles about 2,6-Difluoro-3-(propylsulfonaMido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 2,6-difluoro-3-(propylsulfonamido)benzoate (1186223-50-6) → 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid (1103234-56-5)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield: 91.0%

N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide (918523-58-7) → 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid (1103234-56-5)

Guidance literature:

With Oxone; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 77.0%

methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate (1186193-95-2) → 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid (1103234-56-5)

Guidance literature:

methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; In water;

upstream raw materials:

2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid benzyl ester

N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide

methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate

2,6-difluoro-3-nitrobenzoic acid

Downstream raw materials:

2,6-difluoro-3-(propylsulfonamido)benzoyl chloride

C₁₄H₂₀F₂N₂O₄S

2,6-difluoro-3-(propane-1-sulfonylamino)-N-quinolin-3-ylbenzamide

2,6-difluoro-N-(3H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonamido)benzamide