3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Base Information

Chemical Name:3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]
CAS No.:72364-88-6
Molecular Formula:C₂₅H₂₂FNO₂S
Molecular Weight:419.52
Hs Code.:

Synonyms:3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

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Chemical Property of 3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Chemical Property:

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Technology Process of 3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

There total 6 articles about 3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1885-14-9
phenyl chloroformate

: 72364-84-2
3-(3-fluorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

: 72364-88-6
3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jm00133a016

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 72364-88-6
3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

4: 79 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

With n-butyllithium; boron trifluoride; sodium hydrogencarbonate; sodium methylsulfinylmethanide; acetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00133a016

Reference yield:

: 1072-85-1
o-fluorobromobenzene

: 72364-88-6
3-(3-fluorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

4: 79 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

With n-butyllithium; boron trifluoride; sodium hydrogencarbonate; sodium methylsulfinylmethanide; acetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00133a016