methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Base Information

Chemical Name:methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate
CAS No.:1426670-25-8
Molecular Formula:C₂₁H₂₆N₂O₄
Molecular Weight:370.448
Hs Code.:

Synonyms:methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

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Chemical Property of methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

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Technology Process of methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

There total 5 articles about methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1426670-23-6
C₂₀H₂₄N₂O₄

: 1426670-25-8
methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: With methanol; sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1426670-17-8
methyl 6-(4-chlorophenyl)-1-(2,4-dimethoxybenzyl)-5-ethyl-4-(methoxymethoxy)-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1426670-25-8
methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 2 h / 100 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 760.05 Torr

3: trifluoroacetic acid / dichloromethane / 20 °C

4: sodium tris(acetoxy)borohydride; methanol / dichloromethane / 1 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; potassium phosphate; palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 1426670-19-0
methyl 6-(4-(1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-1-(2,4-dimethoxybenzyl)-5-ethyl-4-(methoxymethoxy)-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1426670-25-8
methyl 5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 760.05 Torr

2: trifluoroacetic acid / dichloromethane / 20 °C

3: sodium tris(acetoxy)borohydride; methanol / dichloromethane / 1 h / 20 °C

With methanol; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;