6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine

Base Information

• Chemical Name: 6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine
• CAS No.: 23596-25-0
• Molecular Formula: C7H7 Cl N2
• Molecular Weight: 154.5969
• Hs Code.: 2933990090
• Mol file: 23596-25-0.mol

Synonyms:6-Chloro-5-azaindoline

Chemical Property of 6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine

Chemical Property:

• Vapor Pressure: 0.00253mmHg at 25°C
• Melting Point: 115-116 °C
• Boiling Point: 287.2°Cat760mmHg
• PKA: 4.31±0.20(Predicted)
• Flash Point: 127.5°C
• PSA: 24.92000
• Density: 1.291g/cm³
• LogP: 1.84100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine

There total 8 articles about 6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-benzyl-6-chloro-7-cyano-5-azaindoline (66751-32-4) → 6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine (23596-25-0)

Guidance literature:

With phosphoric acid; at 190 - 210 ℃; for 0.5h;

DOI:10.1007/BF00507248

Reference yield: 41.0%

6-chloro-1H-pyrrolo[3,2-c]pyridine (74976-31-1) → 6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine (23596-25-0)

Guidance literature:

6-chloro-1H-pyrrolo[3,2-c]pyridine; With dimethylsulfide borane complex; In tetrahydrofuran; at 68 ℃; for 2h; Inert atmosphere;

In tetrahydrofuran; methanol; at 20 - 68 ℃; for 0.833333h;

Reference yield: 8.0%

6-hydroxy-5-azaindoline (66751-33-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-formyl-6-chloro-5-azaindoline + 1-formyl-6-oxo-5-azaindoline (82040-39-9) + 6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine (23596-25-0)

Guidance literature:

With sodium hydroxide; trichlorophosphate; 1) 50 deg C, 4 h; 2) reflux;

DOI:10.1007/BF00522126

upstream raw materials:

1-benzyl-6-chloro-7-cyano-5-azaindoline

6-hydroxy-5-azaindoline

N,N-dimethyl-formamide

6-chloro-1H-pyrrolo[3,2-c]pyridine

Downstream raw materials:

6-methoxy-5-azaindoline

6-chloro-1H-pyrrolo[3,2-c]pyridine

tert-butyl 6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

6-methoxy-5-azaindole

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