17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan

Base Information

• Chemical Name: 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan
• CAS No.: 159465-52-8
• Molecular Formula: C₅₄H₄₉NO₄
• Molecular Weight: 775.987
• Mol file: 159465-52-8.mol

Synonyms:17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan

Chemical Property of 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan

There total 3 articles about 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

anthracenylmethyl chloride (24463-19-2) + 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-4,5α-epoxy-6β,14-dihydroxymorphinan (159465-47-1) → 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan (159465-52-8)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane;

Reference yield:

β-naltrexol (49625-89-0) → 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan (159465-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / TBAHSO₄, aq. KOH / CH₂Cl₂ / Ambient temperature

2: 55 percent / TBABr, 50percent aq. KOH / CH₂Cl₂

With potassium hydroxide; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane;

Reference yield:

trityl chloride (76-83-5) → 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(9-antracylmethoxy)-4,5α-epoxy-14-hydroxymorphinan (159465-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / TBAHSO₄, aq. KOH / CH₂Cl₂ / Ambient temperature

2: 55 percent / TBABr, 50percent aq. KOH / CH₂Cl₂

With potassium hydroxide; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane;

upstream raw materials:

anthracenylmethyl chloride

17-(cyclopropylmethyl)-3-(triphenylmethoxy)-4,5α-epoxy-6β,14-dihydroxymorphinan

β-naltrexol

trityl chloride