(3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole

Base Information

Chemical Name:(3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole
CAS No.:1354693-84-7
Molecular Formula:C₁₆H₁₇FN₂
Molecular Weight:256.323
Hs Code.:

Synonyms:(3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole

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Chemical Property of (3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole

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Technology Process of (3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole

There total 3 articles about (3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 503111-21-5
(3aR,7aR)-2-(2'-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

: 106-96-7
propargyl bromide

: 1354693-84-7
(3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole

Guidance literature:: (3aR,7aR)-2-(2'-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 48h; Inert atmosphere;
DOI:10.1002/adsc.201100684

Reference yield:

: 114260-11-6
2-fluoro-dithiobenzoic acid S-methyl ester

: 1354693-84-7
(3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: mercury(II) oxide / tetrahydrofuran / 70 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / Inert atmosphere

With sodium hydride; mercury(II) oxide; In tetrahydrofuran;
DOI:10.1039/c2gc35732a

Reference yield:

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 1354693-84-7
(3aR,7aR)-2-(2-fluorophenyl)-1-(prop-2-yn-1-yl)-3a,4,5,6,7,7a-hexahydro-1Hbenzo[d]imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: mercury(II) oxide / tetrahydrofuran / 70 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / Inert atmosphere

With sodium hydride; mercury(II) oxide; In tetrahydrofuran;
DOI:10.1039/c2gc35732a