(3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

Base Information

Chemical Name:(3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole
CAS No.:1354693-88-1
Molecular Formula:C₃₅H₃₄N₅P
Molecular Weight:555.662
Hs Code.:

Synonyms:(3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

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Chemical Property of (3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

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Technology Process of (3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

There total 6 articles about (3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1354693-86-9
(3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

: 15475-27-1,4346-39-8
potassium diphenylphosphine

: 1354693-88-1
(3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

Guidance literature:: In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1002/adsc.201100684

Reference yield:

: 503111-21-5
(3aR,7aR)-2-(2'-fluorophenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

: 1354693-88-1
(3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 48 h / 0 - 20 °C / Inert atmosphere

2.1: sodium azide; copper(II) sulfate; ascorbic acid / water; tert-butyl alcohol / 12 h / 40 °C / Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

With sodium azide; sodium hydride; copper(II) sulfate; ascorbic acid; In tetrahydrofuran; water; mineral oil; tert-butyl alcohol;
DOI:10.1002/adsc.201100684

Reference yield:

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 1354693-88-1
(3aR,7aR)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(diphenylphosphino)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: mercury(II) oxide / tetrahydrofuran / 70 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / Inert atmosphere

3: sodium azide; copper(II) sulphate hydrate; ascorbic acid / Inert atmosphere

4: tetrahydrofuran / Inert atmosphere

With sodium azide; copper(II) sulphate hydrate; sodium hydride; mercury(II) oxide; ascorbic acid; In tetrahydrofuran;
DOI:10.1039/c2gc35732a