tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate

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Chemical Name:tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate
CAS No.:1429233-25-9
Molecular Formula:C₃₃H₃₇ClN₄O₇S
Molecular Weight:669.198
Hs Code.:

Synonyms:tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate

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Chemical Property of tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate

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Technology Process of tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate

There total 5 articles about tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 839718-02-4
4-(chloromethyl)-N-hydroxybenzimidoyl chloride

: 1232423-98-1
tert-butyl N-(3-ethynyl-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)N-tertbutoxycarbonyl-carbamate ?

: 1429233-25-9
tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 22h;

Reference yield:

: 1225062-32-7
tert-butyl N-tert-butoxycarbonyl-N-[5-bromo-3-((trimethylsilyl)ethyynyl)pyrazin-2-yl]carbamate

: 1429233-25-9
tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; bis(tri-tert-butylphasphine)palladium dichloride / water; acetonitrile / 1 h / 20 °C

2: triethylamine / dichloromethane / 22 h / 20 °C

With potassium phosphate; bis(tri-tert-butylphasphine)palladium dichloride; triethylamine; In dichloromethane; water; acetonitrile;

Reference yield:

: 73291-09-5
4-chloromethylbenzaldehyde

: 1429233-25-9
tert-butyl N-tert-butoxycarbonyl-N-[3-[3-[4-(chloromethyl)phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / ethanol / 3 h / 50 °C

2: N-chloro-succinimide; hydrogenchloride / N,N-dimethyl-formamide; 1,4-dioxane / 20 - 33 °C

3: triethylamine / dichloromethane / 22 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;