5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

Base Information

• Chemical Name: 5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
• CAS No.: 1234320-78-5
• Molecular Formula: C₁₆H₂₁FN₄O₃
• Molecular Weight: 336.366

Synonyms:5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

Chemical Property of 5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

Chemical Property:

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Technology Process of 5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

There total 3 articles about 5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (1392411-82-3) → 5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide (1234320-78-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 5h; Reflux;

DOI:10.1134/S1070428012070172

Reference yield:

1-benzyl-5-(2,2-diethoxyethyl)-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one (289651-72-5) → 5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide (1234320-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 7 h / Reflux

2: sodium hydroxide / ethanol / 5 h / Reflux

With potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1134/S1070428012070172

Reference yield:

chloroacetaldehyde diethyl acetal (621-62-5) → 5-amino-N-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide (1234320-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 7 h / Reflux

2: sodium hydroxide / ethanol / 5 h / Reflux

With potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1134/S1070428012070172

upstream raw materials:

5-(2,2-diethoxyethyl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

chloroacetaldehyde diethyl acetal

1-benzyl-5-(2,2-diethoxyethyl)-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one

Downstream raw materials:

1-(4-fluorophenyl)-7-hydroxy-5,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one

7-benzylsulfanyl-1-(4-fluorophenyl)-5,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-4(1H)-one

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