3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

Base Information

Chemical Name:3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid
CAS No.:403857-17-0
Molecular Formula:C₃₄H₅₀N₂O₉S
Molecular Weight:662.845
Hs Code.:

Synonyms:3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

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Chemical Property of 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

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Technology Process of 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

There total 16 articles about 3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 403857-16-9
4-[3-(4-{2-(butane-1-sulfonylamino)-2-[2-(2-carboxy-1,1-dimethyl-ethyl)-3,5-dimethoxy-phenoxycarbonyl]-ethyl}-phenoxy)-propyl]-piperidine-1-carboxylic acid tert-butyl ester

: 403857-17-0
3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/ol010282n

Reference yield:

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 403857-17-0
3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / 1N NaOH / dioxane

2: 80 percent / CBr₄; PPh₃ / CH₂Cl₂

3: 88 percent / NaH / dimethylformamide

4: 95 percent / H₂ / 10percent Pd/C / ethanol

5: 67 percent / DCC; DMAP / CH₂Cl₂ / 22 h / 0 - 20 °C

6: AcOH; H₂O / tetrahydrofuran

7: PCC / CH₂Cl₂

8: KMnO₄ / acetone; H₂O

9: 90 percent / TFA / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; potassium permanganate; carbon tetrabromide; water; hydrogen; sodium hydride; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol010282n

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 403857-17-0
3-(2-{(S)-2-(Butane-1-sulfonylamino)-3-[4-(3-piperidin-4-yl-propoxy)-phenyl]-propionyloxy}-4,6-dimethoxy-phenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / H₂; AcOH / 10percent Pd/C / 20 °C / 2585.81 Torr

2: 92 percent / 1N NaOH / dioxane

3: 80 percent / CBr₄; PPh₃ / CH₂Cl₂

4: 88 percent / NaH / dimethylformamide

5: 95 percent / H₂ / 10percent Pd/C / ethanol

6: 67 percent / DCC; DMAP / CH₂Cl₂ / 22 h / 0 - 20 °C

7: AcOH; H₂O / tetrahydrofuran

8: PCC / CH₂Cl₂

9: KMnO₄ / acetone; H₂O

10: 90 percent / TFA / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; potassium permanganate; carbon tetrabromide; water; hydrogen; sodium hydride; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol010282n