4-Piperidinepropanol

Base Information

• Chemical Name: 4-Piperidinepropanol
• CAS No.: 7037-49-2
• Molecular Formula: C8H17 N O
• Molecular Weight: 143.229
• Hs Code.: 2933399090
• European Community (EC) Number: 230-318-7
• DSSTox Substance ID: DTXSID5064546
• Nikkaji Number: J227.345D
• Wikidata: Q72500942
• ChEMBL ID: CHEMBL4595993
• Mol file: 7037-49-2.mol

Synonyms:7037-49-2;4-Piperidinepropanol;3-(piperidin-4-yl)propan-1-ol;3-(4-Piperidyl)-1-propanol;3-Piperidin-4-yl-propan-1-ol;3-piperidin-4-ylpropan-1-ol;Piperidine-4-propanol;4-(3-Hydroxypropyl)piperidine;3-(4-piperidinyl)-1-propanol;EINECS 230-318-7;MFCD02178380;4-hydroxypropylpiperidine;4-Piperidine-1-propanol;3-(4-piperidyl)propanol;3-(4-piperidinyl)propanol;SCHEMBL28893;3-piperdin-4-yl-propan-1-ol;CHEMBL4595993;DTXSID5064546;3-(piperidin-4-yl)-1-propanol;3-(piperidin-4-yl)-propan-1-ol;AMY34788;BCP18232;STK503300;AKOS005171575;CS-W002891;SB10960;SY002538;TS-01873;3-(4-Piperidinyl)-1-propanol AldrichCPR;3-(4-Piperidinyl)-1-propanol, AldrichCPR;A9285;BB 0237086;FT-0658334;EN300-130609;Q-102145

Chemical Property of 4-Piperidinepropanol

Chemical Property:

• Vapor Pressure: 0.0091mmHg at 25°C
• Melting Point: 65 °C
• Boiling Point: 235.5°Cat760mmHg
• PKA: 15.16±0.10(Predicted)
• Flash Point: 90.2°C
• PSA: 32.26000
• Density: 0.929g/cm³
• LogP: 1.08730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 79.3

Purity/Quality:

99.0% ^*data from raw suppliers

4-(3-Hydroxypropyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1CCCO
• Uses: piperidine-4-propanol is used in the synthesis of G-protein coupled receptor (GPR119) agonists based on a bicyclic amine scaffold. Also used in the synthesis and antimicrobial activities of no vel quinoline derivatives. 4-(3-Hydroxypropyl)piperidine is used in the synthesis of G-protein coupled receptor (GPR119) agonists based on a bicyclic amine scaffold. Also used in the synthesis and antimicrobial activities of novel quinoline derivatives.

Technology Process of 4-Piperidinepropanol

There total 9 articles about 4-Piperidinepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(3-Hydroxypropyl)pyridine (2629-72-3) → 3-(piperidin-4-yl)propan-1-ol (7037-49-2)

Guidance literature:

With hydrogenchloride; Adam’s catalyst; hydrogen; In methanol; water; for 46h; under 60.006 Torr; Inert atmosphere;

DOI:10.1016/j.bmc.2015.01.015

Reference yield: 43.0%

3-(pyridin-4-yl)propane-2-yn-1-ol (93524-95-9) → 3-(piperidin-4-yl)propan-1-ol (7037-49-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In acetic acid; at 20 ℃; for 6h; under 760.051 Torr; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.06.022

Reference yield:

N-Boc-piperidin-4-yl-propanol (156185-63-6) → 3-(piperidin-4-yl)propan-1-ol (7037-49-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2012.05.117

upstream raw materials:

4-(3-Hydroxypropyl)pyridine

ethyl 3-(piperid-4-yl)propionate

N-Boc-piperidin-4-yl-propanol

4-iodopyridine

Downstream raw materials:

N-benzoyl-4-(3-hydroxypropyl)piperidine

benzyl 4-(2-hydroxypropyl)-1-piperidinecarboxylate

3-[1-(4-Nitro-phenyl)-piperidin-4-yl]-propan-1-ol

3-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)propan-1-ol

Refernces

• 1、 -. "METHOD FOR PRODUCING PIPERIDINE COMPOUND". Paragraph 0057; 0058; 0060. . Retrieved 2018/04/18.
• 2、 -. "9H-PYRROLO-DIPYRIDINE DERIVATIVES". . . Retrieved 2016/09/22.