5-(2-Fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:5-(2-Fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS No.:2648-01-3
Molecular Formula:C₁₅H₁₁FN₂O
Molecular Weight:254.259
Hs Code.:
ChEMBL ID:CHEMBL147024
DSSTox Substance ID:DTXSID70877685
Nikkaji Number:J433.060I

Synonyms:2648-01-3;CHEMBL147024;5-(2-Fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;SCHEMBL8547651;DTXSID70877685;ZFYAQIQNROJRTO-UHFFFAOYSA-N;BDBM50408026;Ro-054336;Ro-05-4336;1,4-BENZODIAZPIN-2-ONE,5-(2-F PH);A849663;1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one

Suppliers and Price of 5-(2-Fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 5-(2-Fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:425.396°C at 760 mmHg
Flash Point:211.072°C
Density:1.283g/cm³
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:254.08554114
Heavy Atom Count:19
Complexity:382

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(=O)NC2=CC=CC=C2C(=N1)C3=CC=CC=C3F

Technology Process of 5-(2-Fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

There total 3 articles about 5-(2-Fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 99833-84-8
N-<2-(2-fluorobenzoyl)phenyl>phthalimidoacetamide

: 2648-01-3
5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: With hydrazine; In methanol; water; at 60 ℃; for 3h;
DOI:10.1135/cccc19851064

Reference yield:

: 2-[(2-bromoacetyl)amino]-2-fluorobenzophenone

: 2648-01-3
5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: With ammonia; In methanol;

Reference yield:

: 1581-13-1
2-amino-2'-fluorobenzophenone

: 2648-01-3
5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / CHCl₃ / 6 h / Heating

2: 94 percent / N₂H₄ / methanol; H₂O / 3 h / 60 °C

With hydrazine; In methanol; chloroform; water;
DOI:10.1135/cccc19851064