3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide

Base Information

Chemical Name:3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide
CAS No.:1307810-42-9
Molecular Formula:C₂₆H₂₃F₃N₄O₃
Molecular Weight:496.489
Hs Code.:

Synonyms:3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide

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Chemical Property of 3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide

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Technology Process of 3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide

There total 12 articles about 3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307812-51-6
7-(bromomethyl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

: 4874-17-3
N-methyl-β-alaninamide

: 1307810-42-9
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307810-42-9
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere

5.2: 1.17 h / 0 °C

5.3: 3 h / 110 °C / Inert atmosphere

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / chloroform; water; tetrahydrofuran / 20 °C

6.2: 2 h / 20 °C / Inert atmosphere

7.1: phosphorus tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

8.1: triethylamine / N,N-dimethyl-formamide / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; osmium(VIII) oxide; n-butyllithium; lithium hydroxide monohydrate; phosphorus tribromide; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; trifluoroacetic acid; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307810-42-9
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere

4.2: 1.17 h / 0 °C

4.3: 3 h / 110 °C / Inert atmosphere

5.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / chloroform; water; tetrahydrofuran / 20 °C

5.2: 2 h / 20 °C / Inert atmosphere

6.1: phosphorus tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: triethylamine / N,N-dimethyl-formamide / 20 °C

With pyridine; osmium(VIII) oxide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;