(1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester
CAS No.:862174-81-0
Molecular Formula:C₃₀H₄₈N₄O₇
Molecular Weight:576.734
Hs Code.:

(1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

Synonyms:(1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

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Chemical Property of (1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

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Technology Process of (1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

There total 1 articles about (1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 787548-29-2,213316-32-6,259221-73-3
(1R,2S)/(1S,2R) 1-amino-2-vinylcyclopropane carboxylic acid ethyl ester

: C₂₂H₃₇N₃O₆

: 862174-81-0
(1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: (1R,2S)/(1S,2R) 1-amino-2-vinylcyclopropane carboxylic acid ethyl ester; C₂₂H₃₇N₃O₆; With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 0 ℃;

With HATU; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 2h;

Reference yield: 10.0%

: 300831-05-4,898534-17-3
2-[2-(isopropylamino)-1,3-thiazol-4-yl]-7-methoxyquinolin-4-ol

: 862174-81-0
(1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

: (1R)-1-[[[(1R,2R,4S)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-[[7-methoxy-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-4-quinolinyl]oxy]cyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: 2-[2-(isopropylamino)-1,3-thiazol-4-yl]-7-methoxyquinolin-4-ol; (1R)-1-[[[(1R,2R,4R)-2-[[[(1S)-1-[[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-4-hydroxycyclopentyl]carbonyl]amino]-2-ethenyl-cyclopropanecarboxylic acid ethyl ester; With triphenylphosphine; In tetrahydrofuran; at 0 ℃;

With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 49.0833h;