(R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Base Information

Chemical Name:(R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
CAS No.:1346653-88-0
Molecular Formula:C₄₄H₄₈N₆O₈S
Molecular Weight:820.967
Hs Code.:

(R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Synonyms:(R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

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Chemical Property of (R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

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Technology Process of (R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

There total 9 articles about (R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346655-75-1
(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

: 1346653-88-0
(R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 16h;

Reference yield:

: 801311-41-1
3-[[3-carbamoyl-4-[(3-methoxyphenyl)amino]-8-methylquinolin-6-yl]sulfonyl]benzoic acid

: 1346653-88-0
(R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

2: Dess-Martin periodane / N,N-dimethyl-formamide / 3 h / 20 °C

3: acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

5: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 16 h

With tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 19008-71-0
8-aminooctan-1-ol

: 1346653-88-0
(R)-6-[[3-[[8-[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

2: Dess-Martin periodane / N,N-dimethyl-formamide / 3 h / 20 °C

3: acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

5: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 16 h

With tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;