(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Base Information

Chemical Name:(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
CAS No.:1346655-75-1
Molecular Formula:C₅₀H₆₂N₆O₈SSi
Molecular Weight:935.229
Hs Code.:

(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Synonyms:(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

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Chemical Property of (R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Chemical Property:

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Technology Process of (R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

There total 8 articles about (R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₀H₆₀N₆O₈SSi

: 1346655-75-1
(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 801311-41-1
3-[[3-carbamoyl-4-[(3-methoxyphenyl)amino]-8-methylquinolin-6-yl]sulfonyl]benzoic acid

: 1346655-75-1
(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

2: Dess-Martin periodane / N,N-dimethyl-formamide / 3 h / 20 °C

3: acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

With sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 1346655-75-1
(R)-6-[[3-[[8-[[2-[(tert-butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 - 80 °C

2: hydrogen; palladium hydroxide, 20 wt% on carbon / methanol

3: acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

With sodium azide; palladium hydroxide, 20 wt% on carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In methanol; N,N-dimethyl-formamide;