Technology Process of 7-(3-chloro-phenylamino)-3-methyl-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid
There total 10 articles about 7-(3-chloro-phenylamino)-3-methyl-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C17H16ClN3O2;
With
potassium hydroxide; ethanol; water;
Heating / reflux;
With
hydrogenchloride;
Product distribution / selectivity;
- Guidance literature:
-
With
hydrogenchloride;
In
water;
pH=1;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid; acetic acid; periodic acid / water / 0.25 h / 90 °C
1.2: 0.33 h
2.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C
3.1: tetrahydrofuran / 0.92 h / 0 °C
4.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 80 °C
5.1: methanesulfonic acid / 1,4-dioxane / 0.5 h / 180 °C / Microwave
6.1: methanol; potassium hydroxide; water / 1,4-dioxane / Heating / reflux
6.2: pH 1
With
methanol; potassium hydroxide; methanesulfonic acid; sulfuric acid; water; acetic acid; O-phenyl phosphorodichloridate; periodic acid; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1,4-dioxane; water;
