[3R-(1(S^*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Base Information

• Chemical Name: [3R-(1(S^*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one
• CAS No.: 133963-43-6
• Molecular Formula: C₂₅H₂₇F₃N₂O₄
• Molecular Weight: 476.496

Synonyms:[3R-(1(S^*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Chemical Property of [3R-(1(S^*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Chemical Property:

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Technology Process of [3R-(1(S^*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

There total 22 articles about [3R-(1(S^*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R-cis)-3-(hydroxy)-1,3,4,5-tetrahydro-4-[4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (127061-43-2) → [3R-(1(S*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (133963-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Cs₂CO₃ / dimethylformamide / 50 °C

2: ethyl acetate / 70 °C

3: H₂ / Pd(OH)2 / ethyl acetate; trifluoroacetic acid

With hydrogen; caesium carbonate; palladium dihydroxide; In ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid;

Reference yield:

<3R-<1(S*),3α,4α>>-1-<<(benzyloxycarbonyl)-2-pyrrolidinyl>methyl>-1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (134932-93-7) → [3R-(1(S*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (133963-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate / 70 °C

2: H₂ / Pd(OH)2 / ethyl acetate; trifluoroacetic acid

With hydrogen; palladium dihydroxide; In ethyl acetate; trifluoroacetic acid;

Reference yield:

(2S)-2-(4-methylphenylsulfonyloxymethyl)-pyrrolidine-1-carboxylic acid benzyl ester (72500-24-4) → [3R-(1(S*),3α,4α)]-3-(acetyloxy)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-1-(2-pyrrolidinylmethyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (133963-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Cs₂CO₃ / dimethylformamide / 50 °C

2: ethyl acetate / 70 °C

3: H₂ / Pd(OH)2 / ethyl acetate; trifluoroacetic acid

With hydrogen; caesium carbonate; palladium dihydroxide; In ethyl acetate; N,N-dimethyl-formamide; trifluoroacetic acid;

upstream raw materials:

2-methyl-1-nitro-3-(trifluoromethyl)benzene

dimethyl 2-(4-methoxybenzylidene)malonate

[2-(2-amino-6-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester

(3R-cis)-3-(hydroxy)-1,3,4,5-tetrahydro-4-[4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

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