6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline

Base Information

Chemical Name:6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline
CAS No.:190278-39-8
Molecular Formula:C₄₉H₄₅NO₉
Molecular Weight:791.898
Hs Code.:

Synonyms:6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline

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Chemical Property of 6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline

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Technology Process of 6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline

There total 11 articles about 6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 29973-94-2
6-(benzyloxy)-1-(4-(benzyloxy)-3-methoxybenzyl)-7-methoxyIsoquinoline

: 190278-33-2
4-Benzyloxy-5-methoxy-2-methoxymethoxy-benzoic acid methyl ester

: 190278-39-8
6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at 32 ℃; for 3.5h;
DOI:10.1016/S0040-4020(97)00287-1

Reference yield:

: 63909-29-5
(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

: 190278-39-8
6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / Na / CH₂Cl₂ / 0.08 h / Ambient temperature

2: 8.45 g / LiAlH₄ / diethyl ether; tetrahydrofuran / 3.5 h / Heating

3: 1.) DCC / 1.) CH₂Cl₂, 0 deg C, 25 min, 2.) CH₂Cl₂, room temp., overnight

4: 57 percent / POCl₃ / benzene / 2.5 h / Heating

5: 63 percent / LDA / tetrahydrofuran / 3.5 h / 32 °C

With lithium aluminium tetrahydride; sodium; dicyclohexyl-carbodiimide; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4020(97)00287-1

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 190278-39-8
6-benzyloxy-1-[1-(3-benzyloxy-4-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]-7-methoxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) K₂CO₃ / 1.) acetone, room temp., 1 h, 2.) acetone, reflux, 3.5 h

2: 91 percent / Br₂ / CHCl₃ / 1.5 h / Ambient temperature

3: 63 percent / Na, CuCl₂ / dimethylformamide / 1 h / 110 - 115 °C

4: 1.) t-BuOK / 1.) THF, 30 min, 2.) THF, room temp., 4 h

5: 63 percent / LDA / tetrahydrofuran / 3.5 h / 32 °C

With potassium tert-butylate; bromine; sodium; potassium carbonate; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00287-1