2150-47-2

Basic information

• Product Name: Methyl 2,4-dihydroxybenzoate
• Synonyms: RARECHEM AL BF 0221;2,4-dihydroxy-benzoicacimethylester;Benzoic acid, 2,4-dihydroxy-, methyl ester;Methyl benzoate, 2,4-dihydroxy-;METHYL B-RESORCYLATE;METHYL BETA-RESORCYLATE;METHYL 2,4-DIHYDROXYBENZOATE;BETA-RESORCYLIC ACID METHYL ESTER
• CAS NO: 2150-47-2
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• EINECS: 218-428-3
• Product Categories: Intermediates of Dyes and Pigments;Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters;Building Blocks;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 2150-47-2.mol
• Article Data: 45

Chemical Properties

• Melting Point: 118-121 °C(lit.)
• Boiling Point: 257.07°C (rough estimate)
• Flash Point: 148.8 °C
• Appearance: White to beige/Powder
• Density: 1.3037 (rough estimate)
• Vapor Pressure: 1.95E-05mmHg at 25°C
• Refractive Index: 1.5090 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in methanol.
• PKA: 8.14±0.18(Predicted)
• CAS DataBase Reference: Methyl 2,4-dihydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,4-dihydroxybenzoate(2150-47-2)
• EPA Substance Registry System: Methyl 2,4-dihydroxybenzoate(2150-47-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 2150-47-2(Hazardous Substances Data)

Usage

Chemical Properties

white to beige powder

Uses

Methyl 2,4-dihydroxybenzoate is used as a cosmetic agents. And it is used in synthesis of raw material for fine chemicals, organic intermediate, pharmaceutical intermediate.

InChI:InChI=1/C8H8O4/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4,9-10H,1H3

Synthetic route

methanol (67-56-1) + 4-hydroxysalicylic acid (89-86-1) → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
With sulfuric acid for 72h; Heating;	100%
With sulfuric acid In water for 120h; Reflux; Inert atmosphere;	100%
With sulfuric acid for 20h; Reflux;	99%

methyl 2,4-diacetoxybenzoate (106315-78-0) → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
With trimethyltin hydroxide In 1,2-dichloro-ethane at 80℃; for 5h;	100%

4-hydroxysalicylic acid (89-86-1) + methyl iodide (74-88-4) → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 40℃;	94%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile for 24h; Ambient temperature;	85%
Stage #1: 4-hydroxysalicylic acid With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; Stage #2: methyl iodide In N,N-dimethyl-formamide at 40℃; for 10h;	84.4%

2-hydroxy-4-(tetrahydropyran-2-yloxy)-benzoic acid methyl ester → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
With calcium chloride In ethanol; water at 19.85 - 179.85℃; under 7575.61 Torr; for 0.666667h;	94%

methyl 2,4-diacetoxybenzoate (106315-78-0) → methyl 2,4-dihydroxybenzoate (2150-47-2) + methyl 2-acetoxy-4-hydroxybenzoate (113951-79-4)

Conditions	Yield
With porcine pancreatic lipase In tetrahydrofuran; butan-1-ol at 28 - 30℃; for 552h;	A 5% B 90%
With Candida cylindracea lipase In di-isopropyl ether; butan-1-ol at 28 - 30℃; for 18h;	A 47% B 48%

methyl 2,4-dimethoxymethyloxybenzoate (914298-92-3) → methyl 2,4-dihydroxybenzoate (2150-47-2) + methyl 2-hydroxy-4-methoxymethyloxybenzoate (130483-44-2)

Conditions	Yield
With silica-immobilized p-TsOH In toluene at 0℃; for 0.5h;	A 4% B 86%

methyl 4-chloro-2-hydroxybenzoate (22717-55-1) → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
With formic acid; oxygen; triethylamine; copper(ll) bromide In acetonitrile at 20℃; for 48h; Irradiation;	81%

methyl 2,4-diisopropoxybenzoate (945745-54-0) → methyl 2,4-dihydroxybenzoate (2150-47-2) + methyl 2-hydroxy-4-isopropoxybenzoate (163618-93-7)

Conditions	Yield
With amberlyst-15 In toluene at 80℃; for 3h;	A 2% B 80%

methanol (67-56-1) + 2,4-Dihydroxybenzaldehyde (95-01-2) → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
Stage #1: methanol; 2,4-Dihydroxybenzaldehyde With tris(pentafluorophenyl)borate for 0.25h; Green chemistry; Stage #2: With tert.-butylhydroperoxide In decane for 36h; Green chemistry;	79%
With 1-(ferrocenylbutyl)-4-(3-methylimidazolium) chloride; iodine; potassium carbonate at 50 - 60℃; for 24h; Inert atmosphere;	43%

methyl 2,4-di-(4-methoxy-benzyloxy)benzoate (1165713-03-0) → methyl 2,4-dihydroxybenzoate (2150-47-2) + methyl 2-hydroxy-4-(4-methoxy-benzyloxy)benzoate (148965-89-3)

Conditions	Yield
With silica-immobilized p-TsOH In toluene at 65℃; for 0.5h;	A 16% B 68%

methanol (67-56-1) + 2-benzoyloxy-4-hydroxybenzoic acid (54930-57-3) → methyl 2,4-dihydroxybenzoate (2150-47-2) + methyl 2-benzoyloxy-4-hydroxybenzoate

Conditions	Yield
With hydrogenchloride	A 46% B 9.5%

1,3,5-tris(trimethylsiloxy)-1-methoxyhexa-1,3,5-triene (102342-54-1) + trimethyl orthoformate (149-73-5) → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
With titanium tetrachloride In dichloromethane 1.) -78 deg C, 2-3 h, 2.) RT, overnight;	35%

2-hydroxy-4-(2-propenyloxy)benzoic acid methyl ester (79557-58-7) → methyl 2,4-dihydroxybenzoate (2150-47-2) + 2,4-Dihydroxy-5-(2-hydroxy-propyl)-benzoic acid methyl ester + 2,4-Dihydroxy-3-(2-hydroxy-propyl)-benzoic acid methyl ester

Conditions	Yield
With trifluoroacetic acid Heating;	A 17% B 10% C 3.5%
With trifluoroacetic acid Heating;	A 17% B 10% C 3.5%
With trifluoroacetic acid Heating;	A 17% B 10% C 3.5%

diazomethane (186581-53-3, 908094-01-9) + 4-hydroxysalicylic acid (89-86-1) → methyl 2,4-dihydroxybenzoate (2150-47-2)

mulberrofuran M (101365-03-1) → methyl 2,4-dihydroxybenzoate (2150-47-2) + C27H18O7 (103196-93-6)

Conditions	Yield
With sulfuric acid In methanol

hydrogenchloride (7647-01-0) + 2,4-dihydroxy-benzimidic acid methyl ester → methyl 2,4-dihydroxybenzoate (2150-47-2)

2-acetoxy-4-benzoyloxy-benzoic acid methyl ester (861514-29-6) + ammonia (7664-41-7) + acetone (67-64-1) → methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
at 20℃;

4-hydroxysalicylic acid (89-86-1) → [4-(pyridin-3-ylmethyloxy)-2-phenylbenzoyl]methionine + methyl 2,4-dihydroxybenzoate (2150-47-2)

Conditions	Yield
With sulfuric acid; trimethyl orthoformate In methanol

methyl 2,4-dihydroxybenzoate (2150-47-2) + tert-butyldimethylsilyl chloride (18162-48-6) → methyl 2,4-bis<(tert-butyldimethylsilyl)oxy>benzoate (132297-26-8)

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃; for 0.5h;	100%
Stage #1: methyl 2,4-dihydroxybenzoate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 0℃; for 2h; Inert atmosphere;	100%
Stage #1: methyl 2,4-dihydroxybenzoate With sodium hydride In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	94%
With sodium hydride 1a) THF, 0 deg C, 25 min, 1b) 25 deg C, 30 min, 2) 25 deg C, 12h; Yield given. Multistep reaction;

methyl 2,4-dihydroxybenzoate (2150-47-2) + isopropyl bromide (75-26-3) → methyl 2,4-diisopropoxybenzoate (945745-54-0)

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; caesium carbonate In N,N-dimethyl-formamide; acetone Reflux; Inert atmosphere;	100%

methyl 2,4-dihydroxybenzoate (2150-47-2) + benzoyl chloride (98-88-4) → [4-(2-hydroxymethoxycarbonyl)phenyl]benzoate (109337-51-1)

Conditions	Yield
With sodium iodide; potassium carbonate In water; acetone	99%
With triethylamine In dichloromethane at 0 - 20℃; for 24h;	83.1%
With pyridine In diethyl ether; benzene at 20℃; for 10h;	32%

1-Bromodocosane (6938-66-5) + methyl 2,4-dihydroxybenzoate (2150-47-2) → methyl 2,4-di(docosyloxy)benzoate

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 16h; Inert atmosphere;	98%
With desipramine; potassium carbonate
With 1,3-dimethyl-2-imidazolidinone; potassium carbonate
With potassium carbonate

1-Iodoheptane (4282-40-0) + methyl 2,4-dihydroxybenzoate (2150-47-2) → 2-hydroxy-4-(octadecyloxy)benzoic acid methyl ester

Conditions	Yield
With potassium carbonate In acetone Reflux; Inert atmosphere;	98%

methyl 2,4-dihydroxybenzoate (2150-47-2) + 3-bromopropylamine tert-butylcarbamate (83948-53-2) → methyl 2,4‐bis(3‐((tert‐butoxycarbonyl)amino)propoxy)benzoate

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 40℃;	97%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 31h;	75%

methyl 2,4-dihydroxybenzoate (2150-47-2) + N-tosylimidazole (2232-08-8) → methyl 2,4-bis(tosyloxy)benzoate (137668-92-9)

Conditions	Yield
With TEA; methyl trifluoromethanesulfonate In tetrahydrofuran 1.) ice/water bath, 20 min, 2.) r. t., overnight;	96%

methyl 2,4-dihydroxybenzoate (2150-47-2) + benzyl bromide (100-39-0) → methyl 2,4-bis(benzyloxy)benzoate (85593-76-6)

Conditions	Yield
With potassium carbonate In acetone for 6h; Heating;	95%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 18h; Inert atmosphere; Reflux;	94%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 18h; Reflux;	94%

methyl 2,4-dihydroxybenzoate (2150-47-2) + benzyl bromide (100-39-0) → methyl 2-hydroxy-4-benzyloxybenzoate (5427-29-2)

Conditions	Yield
Stage #1: methyl 2,4-dihydroxybenzoate With potassium carbonate In acetone at 0 - 20℃; for 1h; Stage #2: benzyl bromide In acetone at 0℃; Temperature; Reflux;	95%
Stage #1: methyl 2,4-dihydroxybenzoate With potassium carbonate In acetone at 20℃; for 0.0833333h; Stage #2: benzyl bromide In acetone at 10 - 15℃;	85%
With potassium carbonate In acetone at 10 - 15℃; for 3h; Inert atmosphere;	82%

trifluoromethylsulfonic anhydride (358-23-6) + methyl 2,4-dihydroxybenzoate (2150-47-2) → 2-hydroxy-4-trifluoromethanesulfonyloxybenzoic acid methyl ester (149878-72-8)

Conditions	Yield
With pyridine; dmap In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;	95%
With pyridine; dmap In dichloromethane at 0 - 20℃;	46%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	35%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	35%
With pyridine; dmap In dichloromethane at 0℃;

di-tert-butyl dicarbonate (24424-99-5) + methyl 2,4-dihydroxybenzoate (2150-47-2) → 2,4-bis-tert-butoxycarbonyloxy-benzoic acid methyl ester

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 4h;	94%

Chlorodiisopropylphosphane (40244-90-4) + methyl 2,4-dihydroxybenzoate (2150-47-2) → C20H34O4P2 (1394791-95-7)

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1h;	94%
Stage #1: methyl 2,4-dihydroxybenzoate With triethylamine In tetrahydrofuran at 20℃; Inert atmosphere; Schlenk technique; Glovebox; Stage #2: Chlorodiisopropylphosphane In tetrahydrofuran at 20℃; Inert atmosphere; Schlenk technique; Glovebox;

methyl 2,4-dihydroxybenzoate (2150-47-2) + 2,5-dichloro-3-(ethoxymethoxy)benzyl alcohol → methyl 4-(2,5-dichloro-3-(ethoxymethoxy)benzyloxy)-2-hydroxybenzoate

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h;	94%

methyl 2,4-dihydroxybenzoate (2150-47-2) + chloromethyl methyl ether (107-30-2) → methyl 2-hydroxy-4-methoxymethyloxybenzoate (130483-44-2)

Conditions	Yield
Stage #1: methyl 2,4-dihydroxybenzoate With potassium carbonate In acetone at 20℃; for 0.0833333h; Stage #2: chloromethyl methyl ether In acetone at 10 - 15℃;	92%
Stage #1: methyl 2,4-dihydroxybenzoate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: chloromethyl methyl ether In tetrahydrofuran at 0 - 20℃; for 1h;	89%
With potassium carbonate In butanone at 60℃; for 48h;	81%
With potassium carbonate In butanone at 60℃; for 48h;	81%

methyl 2,4-dihydroxybenzoate (2150-47-2) + chloromethyl methyl ether (107-30-2) → methyl 2,4-dimethoxymethyloxybenzoate (914298-92-3)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 23℃; for 12h;	92%

methyl 2,4-dihydroxybenzoate (2150-47-2) + methoxymethyl halide → methyl 2,4-dimethoxymethyloxybenzoate (914298-92-3)

Conditions	Yield
Stage #1: methyl 2,4-dihydroxybenzoate With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: methoxymethyl halide In N,N-dimethyl-formamide at 100℃;	92%

methyl 2,4-dihydroxybenzoate (2150-47-2) + methyl iodide (74-88-4) → 4-methoxymethylsalicylate (5446-02-6)

Conditions	Yield
With potassium carbonate In acetone for 3h; Reflux;	92%
With potassium carbonate In acetone Reflux; Inert atmosphere;	90%
With potassium carbonate In acetone Reflux;	90%

methyl 2,4-dihydroxybenzoate (2150-47-2) + tert-butyl alcohol (75-65-0) → methyl 5-tert-butyl-2,4-dihydroxybenzoate (1352754-47-2)

Conditions	Yield
With sulfuric acid at 60℃; for 94h;	91%

formaldehyd (50-00-0) + methyl 2,4-dihydroxybenzoate (2150-47-2) + chitosan hydrochloride L0221-20FD, DDA 90%, Mw 5 kDa, Mn 2 kDa → N-((2,6-dihydroxy-3-carboxymethyl)phenyl)methylated chitosan DS 0.1

Conditions	Yield
Stage #1: formaldehyd; chitosan hydrochloride L0221-20FD, DDA 90%, Mw 5 kDa, Mn 2 kDa In water at 65℃; for 1h; Stage #2: methyl 2,4-dihydroxybenzoate In methanol; water at 65℃; for 24h;	91%

2-chloroethyl methyl ether (627-42-9) + methyl 2,4-dihydroxybenzoate (2150-47-2) → methyl 2-hydroxy-4-(2-methoxyethoxy)benzoate (553672-08-5)

Conditions	Yield
Stage #1: methyl 2,4-dihydroxybenzoate With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 0.166667h; Stage #2: 2-chloroethyl methyl ether In N,N-dimethyl-formamide at 90℃; for 12.5h;	91%

methyl 2,4-dihydroxybenzoate (2150-47-2) → 2,4-dihydroxybenzoic acid hydrazide (13221-86-8)

Conditions	Yield
With hydrazine In methanol for 48h; Heating;	90%
With hydrazine hydrate In ethanol at 20℃;
With hydrazine hydrate Reflux;
With hydrazine hydrate for 4h; Reflux;

methyl 2,4-dihydroxybenzoate (2150-47-2) + p-methoxybenzyl chloride (824-94-2) → methyl 2-hydroxy-4-(4-methoxy-benzyloxy)benzoate (148965-89-3)

Conditions	Yield
Stage #1: methyl 2,4-dihydroxybenzoate With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: p-methoxybenzyl chloride In N,N-dimethyl-formamide at 10 - 15℃;	90%
With potassium carbonate In acetone Heating / reflux;
With tetrabutylammomium bromide; potassium carbonate; potassium iodide In acetone for 3h; Reflux;

1-bromo-butane (109-65-9) + methyl 2,4-dihydroxybenzoate (2150-47-2) → C19H30O4 + 2,4-Dibutoxy-benzoic acid methyl ester

Conditions	Yield
Stage #1: methyl 2,4-dihydroxybenzoate With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Stage #2: 1-bromo-butane In N,N-dimethyl-formamide at 20℃; for 96h; Inert atmosphere;	A 10% B 90%

1-iodo-butane (542-69-8) + methyl 2,4-dihydroxybenzoate (2150-47-2) → 2-Hydroxy-4-n-butoxybenzoesaeuremethylester (86840-96-2)

Conditions	Yield
With potassium carbonate In acetone Reflux; Inert atmosphere;	90%

methyl 2,4-dihydroxybenzoate (2150-47-2) + 1-dodecylbromide (143-15-7) → 2-Hydroxy-4-n-dodecoxybenzoesaeuremethylester (86840-98-4)

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate; potassium iodide In acetone Heating;	89%
With potassium carbonate In acetone at 60 - 70℃; for 25h; Heating;	69%
With potassium carbonate In acetone for 25h; Heating;	69%

Upstream product

• 186581-53-3 diazomethane 
• 89-86-1 4-hydroxysalicylic acid 
• 7647-01-0 hydrogenchloride 
• 861514-29-6 2-acetoxy-4-benzoyloxy-benzoic acid methyl ester 
• 7664-41-7 ammonia 
• 67-64-1 acetone 
• 22717-55-1 methyl 4-chloro-2-hydroxybenzoate 
• 67-56-1 methanol 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 1165713-03-0 methyl 2,4-di-(4-methoxy-benzyloxy)benzoate 
• 914298-92-3 methyl 2,4-dimethoxymethyloxybenzoate 
• 945745-54-0 methyl 2,4-diisopropyl benzoate 
• 106315-78-0 methyl 2,4-diacetoxybenzoate 
• 54930-57-3 2-benzoyloxy-4-hydroxybenzoic acid 

Downstream Products

• 29264-27-5 2-Hydroxy-4-n-butoxybenzoesaeure 
• 89939-43-5 4-(5-hydroxy-[1,3,4]oxadiazol-2-yl)-benzene-1,3-diol 
• 5427-29-2 methyl 2-hydroxy-4-benzyloxybenzoate 
• 855875-76-2 4,6-dihydroxy-α-oxo-bibenzyl-3-carboxylic acid methyl ester 
• 39503-26-9 5-carbomethoxy-6-hydroxysalicylaldehyde 
• 945745-54-0 methyl 2,4-diisopropyl benzoate 
• 163618-93-7 methyl 2-hydroxy-4-isopropyl benzoate 
• 393519-55-6 methyl 2-hydroxy-4-(n-tetradecyloxy)benzoate 
• 162045-36-5 4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-hydroxybenzoic acid methyl ester 
• 128154-77-8 methyl 6,7,8,9-tetrahydro-3-hydroxydibenzofuran-2-carboxylate 
• 128154-76-7 methyl 6,7,8,9-tetrahydro-1-hydroxydibenzofuran-2-carboxylate 
• 62443-15-6 2-Hydroxy-4-tetradecyloxy-benzoic acid ethyl ester 
• 85593-76-6 methyl 2,4-bis(benzyloxy)benzoate 
• 1214-24-0 3,6-dihydroxy-xanthen-9-one 

Relevant articles and documents

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Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor

Casein kinase 2 (CK2) is a constitutively expressed serine/threonine kinase that has a large diversity of cellular substrates. Thus, CK2 has been associated with a plethora of regulatory functions and dysregulation of CK2 has been linked to disease development in particular to cancer. The broad implications in disease pathology makes CK2 an attractive target. To date, the most advanced CK2 inhibitor is silmitasertib, which has been investigated in clinical trials for treatment of various cancers, albeit several off-targets for silmitasertib have been described. To ascertain the role of CK2 inhibition in cancer, other disease and normal physiology the development of a selective CK2 inhibitor would be highly desirable. In this study we explored the pyrazolo [1,5-a]pyrimidine hinge-binding moiety for the development of selective CK2 inhibitors. Optimization of this scaffold, which included macrocyclization, led to IC20 (31) a compound that displayed high in vitro potency for CK2 (KD = 12 nM) and exclusive selectivity for CK2. X-ray analysis revealed a canonical type-I binding mode for IC20 (31). However, the polar carboxylic acid moiety that is shared by many CK2 inhibitors including silmitasertib was required for potency but limits the cellular activity of IC20 (31) and the cellular IC50 dropped to the low micromolar range. In summary, IC20 (31) represents a highly selective and potent inhibitor of CK2, which can be used as a tool compound to study CK2 biology and potential new applications for the treatment of diseases.

NOVEL COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF

The present invention relates to a novel compound having HSP90 inhibitory activity or a pharmaceutically acceptable salt thereof, and a medicinal use thereof, and composition comprising a dihydroxyphenyl compound or a benzamide compound, which is a novel compound having the HSP90 inhibitory activity of the present invention can effectively inhibit HSP90, and thus can be usefully used as a pharmaceutical composition for preventing or treating HSP90-mediated diseases or a health functional food for preventing or improving HSP90-mediated diseases, which selected from the group consisting of cancer diseases, degenerative neurological diseases and viral infections.