4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile

Base Information

• Chemical Name: 4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile
• CAS No.: 98088-81-4
• Molecular Formula: C₃₂H₃₄FN₅
• Molecular Weight: 507.654
• Mol file: 98088-81-4.mol

Synonyms:4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile

Chemical Property of 4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile

There total 4 articles about 4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine (73734-07-3) → 4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile (98088-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: H₂ / 10 percent Pd/C poisened thiophene / methanol

With hydrogen bromide; hydrogen; sodium carbonate; potassium iodide; Pd/C poisoned thiophene; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00150a029

Reference yield:

ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate (84501-68-8) → 4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile (98088-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: H₂ / 10 percent Pd/C poisened thiophene / methanol

With hydrogen bromide; hydrogen; Pd/C poisoned thiophene; In methanol;

DOI:10.1021/jm00150a029

Reference yield:

1-chloromethyl-4-fluorobenzene (352-11-4) → 4-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-1-phenyl-cyclohexanecarbonitrile (98088-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: H₂ / 10 percent Pd/C poisened thiophene / methanol

With hydrogen bromide; hydrogen; sodium carbonate; potassium iodide; Pd/C poisoned thiophene; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00150a029

upstream raw materials:

4-cyano-4-phenylcyclohexanone

1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

Refernces