5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

Base Information

Chemical Name:5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide
CAS No.:244214-17-3
Molecular Formula:C₆₇H₈₄N₄O₉SSi
Molecular Weight:1149.58
Hs Code.:

5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-<i>d</i>]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(<i>tert</i>-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

Synonyms:5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

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Chemical Property of 5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

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Technology Process of 5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

There total 7 articles about 5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 244214-16-2
5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

: 244214-17-3
5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

Guidance literature:: With dmap; In pyridine; Heating;
DOI:10.1080/07328319908044672

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 244214-17-3
5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: 94 percent / aq. NaOH / methanol

3: 61 percent / DEC / pyridine

4: 86 percent / DMAP / pyridine / Heating

With pyridine; dmap; sodium hydroxide; diethylcarbamazine; In pyridine; methanol; 1: Etherification / 2: Hydrolysis / 3: Substitution / 4: Substitution;
DOI:10.1080/07328319908044672

Reference yield:

: 35013-72-0
biotin N-Hydroxysuccinimide ester

: 244214-17-3
5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: DIPEA / dimethylformamide

2: pyridine

3: 94 percent / aq. NaOH / methanol

4: 61 percent / DEC / pyridine

5: 86 percent / DMAP / pyridine / Heating

With pyridine; dmap; sodium hydroxide; diethylcarbamazine; N-ethyl-N,N-diisopropylamine; In pyridine; methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Etherification / 3: Hydrolysis / 4: Substitution / 5: Substitution;
DOI:10.1080/07328319908044672