N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

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Chemical Name:N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
CAS No.:862370-83-0
Molecular Formula:C₂₉H₄₄N₆O₄Si
Molecular Weight:568.792
Hs Code.:

Synonyms:N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

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Chemical Property of N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

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Technology Process of N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

There total 6 articles about N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 862370-82-9
N²-[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

: 1609-86-5
Tert-butyl isocyanate

: 862370-83-0
N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

Guidance literature:: N²-[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Tert-butyl isocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm0500931

Reference yield:

: 862370-77-2
6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine

: 862370-83-0
N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18.30 g / 2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl₃ / 24 h / 20 °C

2.1: dioxane / 18 h / Heating

3.1: 1.72 g / imidazole / dimethylformamide / 16 h / 20 °C

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 69 percent / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; sodium hydride; N-(benzenesulfonyl)-3-phenyloxaziridine; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0500931

Reference yield:

: 862370-78-3
6-(3,5-dimethoxyphenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7-amine

: 862370-83-0
N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: dioxane / 18 h / Heating

2.1: 1.72 g / imidazole / dimethylformamide / 16 h / 20 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 69 percent / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm0500931