1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

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Chemical Name:1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione
CAS No.:448896-43-3
Molecular Formula:C₃₂H₃₆N₂O₆Si
Molecular Weight:572.733
Hs Code.:

Synonyms:1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

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Chemical Property of 1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

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Technology Process of 1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

There total 1 articles about 1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 3442-82-8
1,3-bis(trimethylsilyl)uracil

: (S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,6-dioxa-bicyclo[3.1.0]hexane

: 287934-00-3
1-((1R,2R,3S)-tetrahydro-2-hydroxy-3-(((4-methoxyphenyl)-diphenylmethoxy)-methyl)-1-furanyl)-2,4(1H,3H)-pyrimidinedione

: 448896-43-3
1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

Guidance literature:: In chloroform-d1; at 20 ℃; for 36h;
DOI:10.1007/s007060200024

Reference yield: 100.0%

: 448896-43-3
1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

: 287934-00-3
1-((1R,2R,3S)-tetrahydro-2-hydroxy-3-(((4-methoxyphenyl)-diphenylmethoxy)-methyl)-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 0.5h;
DOI:10.1007/s007060200024

Reference yield:

: 448896-43-3
1-{(2R,3R,4S)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-trimethylsilanyloxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

: 287933-88-4
1-((1R,3S)-tetrahydro-3-(((4-methoxyphenyl)-diphenylmethoxy)-methyl)-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. HCl / methanol; tetrahydrofuran / 0.5 h / 0 - 20 °C

2: 90 percent / DMAP / CH₂Cl₂ / 3 h / 20 °C

3: 97 percent / AIBN; Bu₃SnH / benzene / 3 h / Heating

With hydrogenchloride; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; methanol; dichloromethane; benzene; 3: Barton-McCombie deoxygenation;
DOI:10.1007/s007060200024