Technology Process of methyl (E)-6-benzyloxy-3-hydroxy-4-hexenoate
There total 4 articles about methyl (E)-6-benzyloxy-3-hydroxy-4-hexenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: LiAlH4, AlCl3 / diethyl ether / 1.) 0 deg C to RT, 30 min; 2.) 2 h
2: pyridinium chlorochromate, Celite / CH2Cl2 / 3 h
3: trimethyl borate, Zn / tetrahydrofuran / 6 h
With
lithium aluminium tetrahydride; aluminium trichloride; Trimethyl borate; Celite; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00299a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridinium chlorochromate, Celite / CH2Cl2 / 3 h
2: trimethyl borate, Zn / tetrahydrofuran / 6 h
With
Trimethyl borate; Celite; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00299a022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 79 percent / camphorsulfonic acid / benzene / 18 h / Heating
2: LiAlH4, AlCl3 / diethyl ether / 1.) 0 deg C to RT, 30 min; 2.) 2 h
3: pyridinium chlorochromate, Celite / CH2Cl2 / 3 h
4: trimethyl borate, Zn / tetrahydrofuran / 6 h
With
lithium aluminium tetrahydride; aluminium trichloride; Trimethyl borate; Celite; camphor-10-sulfonic acid; pyridinium chlorochromate; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00299a022
