ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

Base Information

Chemical Name:ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate
CAS No.:528597-04-8
Molecular Formula:C₁₉H₁₉ClN₂O₆
Molecular Weight:406.823
Hs Code.:

Synonyms:ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

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Chemical Property of ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

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Technology Process of ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

There total 3 articles about ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 528597-01-5
ethyl 2-amino-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

: 528597-04-8
ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

Guidance literature:: With tert.-butylnitrite; copper dichloride; In acetonitrile; at 65 ℃; for 0.333333h;
DOI:10.1002/jhet.5570390613

Reference yield:

: 174666-19-4
4-(3-oxobutyl)benzoic acid ethyl ester

: 528597-04-8
ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium; ethanol / 20 °C

1.2: 75 percent / glacial acetic acid

2.1: 65 percent / methanol / 0.75 h / Heating

3.1: 60 percent / tert-butyl nitrite; CuCl₂ / acetonitrile / 0.33 h / 65 °C

With tert.-butylnitrite; ethanol; sodium; copper dichloride; In methanol; acetonitrile;
DOI:10.1002/jhet.5570390613

Reference yield:

: 528596-98-7
ethyl 4-(5-ethoxycarbonyl-3,5-dioxopentyl)benzoate

: 528597-04-8
ethyl 2-chloro-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / methanol / 0.75 h / Heating

2: 60 percent / tert-butyl nitrite; CuCl₂ / acetonitrile / 0.33 h / 65 °C

With tert.-butylnitrite; copper dichloride; In methanol; acetonitrile;
DOI:10.1002/jhet.5570390613