(-)-(1R,3S)-ethyl 1-(3-cyano-4-pyridyl)-3-hydroxycyclopentanecarboxylate

Base Information

Chemical Name:(-)-(1R,3S)-ethyl 1-(3-cyano-4-pyridyl)-3-hydroxycyclopentanecarboxylate
CAS No.:75684-60-5
Molecular Formula:C₁₄H₁₆N₂O₃
Molecular Weight:260.293
Hs Code.:

Synonyms:(-)-(1R,3S)-ethyl 1-(3-cyano-4-pyridyl)-3-hydroxycyclopentanecarboxylate

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Chemical Property of (-)-(1R,3S)-ethyl 1-(3-cyano-4-pyridyl)-3-hydroxycyclopentanecarboxylate

Chemical Property:

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Technology Process of (-)-(1R,3S)-ethyl 1-(3-cyano-4-pyridyl)-3-hydroxycyclopentanecarboxylate

There total 2 articles about (-)-(1R,3S)-ethyl 1-(3-cyano-4-pyridyl)-3-hydroxycyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5444-01-9
3-cyano-4-methylpyridine

: 74991-79-0,74991-82-5,75684-60-5,75684-61-6
(1S,3R)-1-(3-Cyano-pyridin-4-yl)-3-hydroxy-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / sodium hydride / toluene / 9 h / Heating

2: potassium carbonate / ethanol / 24 h / 15 °C

With sodium hydride; potassium carbonate; In ethanol; toluene;
DOI:10.1016/S0040-4020(01)86137-8

Reference yield:

: 5444-01-9
3-cyano-4-methylpyridine

: 75684-60-5
(-)-(1R,3S)-ethyl 1-(3-cyano-4-pyridyl)-3-hydroxycyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / sodium hydride / toluene / 9 h / Heating

2: 27 percent / potassium carbonate / ethanol / 24 h / 15 °C

With sodium hydride; potassium carbonate; In ethanol; toluene;
DOI:10.1016/S0040-4020(01)86137-8

Reference yield:

: 74991-79-0,74991-82-5,75684-60-5,75684-61-6
(1S,3R)-1-(3-Cyano-pyridin-4-yl)-3-hydroxy-cyclopentanecarboxylic acid ethyl ester

: 74991-81-4
(1R,3S)-1-(3-Cyano-pyridin-4-yl)-3-(toluene-4-sulfonyloxy)-cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / KOH / 2-methyl-propan-2-ol / 1.5 h / Heating

2: 89 percent / Jones reagent / 4 h / Ambient temperature

3: 67 percent / pyridine / 24 h / Ambient temperature

With pyridine; potassium hydroxide; jones reagent; In tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)71454-7